Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ceftazidime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 5/20 | 0.88 |
| ▸ | PPARG | P37231 | 3/20 | 0.88 |
| ▸ | PGR | P06401 | 3/20 | 0.88 |
| ▸ | ESR1 | P03372 | 1/20 | 0.88 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.87 |
| ▸ | HTR2C | P28335 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.63 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.63 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.63 |
| ▸ | ALB | P02768 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 3/20 | 0.56 |
| ▸ | APAF1 | O14727 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.56 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ceftazidime SCHEMBL22368513 | 0.99 | NR1I2 (0.90) | NR1I2PPARGPGRESR1TDP1 | |
| Ceftazidime SCHEMBL12968439 | 0.99 | NR1I2 (0.90) | NR1I2PPARGPGRESR1TDP1 | |
| Ceftazidime SCHEMBL13451860 | 0.99 | NR1I2 (0.90) | NR1I2PPARGPGRESR1TDP1 | |
| Ceftazidime SCHEMBL12374441 | 0.99 | NR1I2 (0.90) | NR1I2PPARGPGRESR1TDP1 | |
| Ceftazidime SCHEMBL20603076 | 0.99 | NR1I2 (0.88) | NR1I2PPARGPGRESR1TDP1 | |
| Ceftazidime SCHEMBL1237409 | 0.99 | NR1I2 (0.88) | NR1I2PPARGPGRESR1TDP1 | |
| Ceftazidime SCHEMBL27993281 | 0.99 | NR1I2 (0.88) | NR1I2PPARGPGRESR1TDP1 | |
| Ceftazidime SCHEMBL1237405 | 0.99 | NR1I2 (0.88) | NR1I2PPARGPGRESR1TDP1 | |
| Ceftazidime SCHEMBL29120318 | 0.97 | NR1I2 (0.86) | NR1I2PPARGPGRESR1TDP1 | |
| Ceftazidime SCHEMBL5594295 | 0.97 | NR1I2 (0.95) | NR1I2PPARGPGRESR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472383-B1 | Pharmaceutical formulations | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-10-29 | — | — | US | disclosed |
| WO-1995028935-A1 | PHARMACEUTICAL FORMULATIONS CONTAINING A BETA-LACTAMASE INHIBITING PENEM IN COMBINATION WITH A BETA-LACTAM ANTIBIOTIC AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS | SMITHKLINE BEECHAM PLC (GB) | 1995-11-02 | — | — | WO | disclosed |