Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 12/20 | 0.53 |
| ▸ | RARA | P10276 | 10/20 | 0.53 |
| ▸ | RARG | P13631 | 9/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.53 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7637191 | 0.96 | RARB (0.53) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL9058220 | 0.92 | RARB (0.65) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL9484975 | 0.88 | RARB (0.67) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL7639400 | 0.88 | RARB (0.65) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL7640480 | 0.87 | RARB (0.46) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL6297429 | 0.85 | MAPT (0.46) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL6297432 | 0.85 | MAPT (0.46) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL7640476 | 0.84 | RARB (0.45) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL6292622 | 0.78 | RARB (0.40) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL6236817 | 0.78 | RARB (0.49) | RARBRARARARGCYP3A4CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355806-B1 | REGULATORS OF CELL PROLIFERATION AND DIFFERENTIATION, AGENTS FOR TREATING SKIN-RELATED DISEASES | ALLERGEN SALES, INC. | 2002-03-12 | — | — | US | disclosed |
| US-5998471-A | SKIN DISORDERS; ANTIINFLAMMATORY AGENTS | ALLERGAN SALES, INC. (US) | 1999-12-07 | — | — | US | disclosed |
| US-5808083-A | Acetylenes disubstituted with a 5 alkyl, aryl or heteroaryl substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity | ALLERGAN (US) | 1998-09-15 | — | — | US | disclosed |
| US-5723620-A | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity | ALLERGAN (US) | 1998-03-03 | — | — | US | disclosed |
| EP-0800517-A1 | ACETYLENES DISUBSTITUTED WITH A 5 OR 8 SUBSTITUTED TETRAHYDRONAPHTHYL OR DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan (US) | 1997-10-15 | — | — | EP | disclosed |
| US-5648514-A | Substituted acetylenes having retinoid-like biological activity | ALLERGAN (US) | 1997-07-15 | — | — | US | disclosed |
| US-5591858-A | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity | ALLERGAN | 1997-01-07 | — | — | US | disclosed |
| US-5543534-A | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity | ALLERGAN | 1996-08-06 | — | — | US | disclosed |
| WO-1996020930-A1 | ACETYLENES DISUBSTITUTED WITH A 5 OR 8 SUBSTITUTED TETRAHYDRONAPHTHYL OR DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-07-11 | — | — | WO | disclosed |
| US-5514825-A | SYNTHETIC RETINOIDS | ALLERGAN, INC. (US) | 1996-05-07 | — | — | US | disclosed |