Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.57 |
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7647552 | 0.93 | PI4KB (0.49) | PI4KBABL1KDM4ELMNAPOLB | |
| SCHEMBL5482981 | 0.77 | CCNK (0.48) | PI4KBLMNANPC1SMN1; SMN2KMT2A | |
| SCHEMBL4528106 | 0.72 | PI4KB (1.00) | PI4KBKDM4EPOLBPIK3CGHSD17B10 | |
| SCHEMBL5487537 | 0.71 | CCNK (0.46) | PI4KBLMNANPC1SMN1; SMN2KMT2A | |
| SCHEMBL13035831 | 0.68 | KMT2A (0.59) | ABL1KDM4ELMNAPOLBNPC1 | |
| SCHEMBL29763634 | 0.66 | ABL1 (0.59) | ABL1KDM4ELMNAPOLBNPC1 | |
| SCHEMBL10619222 | 0.66 | ABL1 (0.65) | PI4KBABL1KDM4ELMNAPOLB | |
| SCHEMBL4507830 | 0.66 | PI4KB (0.87) | PI4KBKDM4EPOLBPIK3CGHSD17B10 | |
| SCHEMBL9835060 | 0.66 | SMN1; SMN2 (0.65) | LMNANPC1SMN1; SMN2KMT2ARAB9A | |
| SCHEMBL21495120 | 0.65 | ABL1 (0.55) | ABL1KDM4ELMNAPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204649-A1 | ARYLMETHYL-CARBONYLAMINO-THIAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001014353-A1 | ARYLMETHYL-CARBONYLAMINO-THIAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA, S.P.A. (IT) | 2001-03-01 | — | — | WO | disclosed |