Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557891 | 0.91 | HSD17B10 (0.56) | HSD17B10ALDH1A1RECQLKMT2AMEN1 | |
| SCHEMBL6556767 | 0.83 | MAPT (0.57) | HSD17B10ALDH1A1RECQLKMT2AMEN1 | |
| SCHEMBL6557884 | 0.80 | HSD17B10 (0.51) | HSD17B10ALDH1A1RECQLKMT2AMEN1 | |
| SCHEMBL6556733 | 0.77 | GAA (0.43) | HSD17B10ALDH1A1RECQLKMT2AMEN1 | |
| Dimethylamine SCHEMBL22445184 | 0.77 | MEN1 (0.51) | HSD17B10ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL30054040 | 0.73 | MAPT (0.68) | HSD17B10ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6556764 | 0.73 | MAPT (0.68) | HSD17B10ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6556896 | 0.73 | MAPT (0.40) | HSD17B10ALDH1A1RECQLKMT2AMEN1 | |
| SCHEMBL6557164 | 0.72 | MEN1 (0.38) | HSD17B10ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6556694 | 0.71 | PTPRF (0.56) | KMT2AMEN1MAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002521430-A | — | — | 2002-07-16 | — | — | JP | claimed |
| EP-1100483-A2 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | Abbott Laboratories (US) | 2001-05-23 | — | — | EP | claimed |
| WO-2000006137-A2 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 2000-02-10 | — | — | WO | claimed |