Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7645479 | 1.00 | KMT2A (0.45) | KMT2AMEN1ABCG2SIGMAR1EPHX2 | |
| SCHEMBL7645477 | 1.00 | KMT2A (0.45) | KMT2AMEN1ABCG2SIGMAR1EPHX2 | |
| SCHEMBL7550661 | 0.99 | KMT2A (0.46) | KMT2AMEN1ABCG2SIGMAR1EPHX2 | |
| SCHEMBL7643039 | 0.99 | KMT2A (0.46) | KMT2AMEN1ABCG2SIGMAR1EPHX2 | |
| SCHEMBL7639653 | 0.99 | KMT2A (0.46) | KMT2AMEN1ABCG2SIGMAR1EPHX2 | |
| SCHEMBL7550660 | 0.99 | KMT2A (0.46) | KMT2AMEN1ABCG2SIGMAR1EPHX2 | |
| SCHEMBL7643036 | 0.99 | KMT2A (0.46) | KMT2AMEN1ABCG2SIGMAR1EPHX2 | |
| SCHEMBL7550960 | 0.91 | KMT2A (0.44) | KMT2AMEN1ABCG2SIGMAR1EPHX2 | |
| SCHEMBL7550962 | 0.91 | KMT2A (0.44) | KMT2AMEN1ABCG2SIGMAR1EPHX2 | |
| SCHEMBL7545820 | 0.91 | KMT2A (0.43) | KMT2AMEN1ABCG2SIGMAR1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462046-B2 | NON-THIAZOLIDINEDIONE PPARGAMMA AGONISTS; USEFUL IN MODULATION OF BLOOD GLUCOSE AND THE INCREASE OF INSULIN SENSITIVITY IN MAMMALS | ADVANCED SYNTECH, LLC | 2002-10-08 | — | — | US | claimed |
| US-6462046-B2 | NON-THIAZOLIDINEDIONE PPARGAMMA AGONISTS; USEFUL IN MODULATION OF BLOOD GLUCOSE AND THE INCREASE OF INSULIN SENSITIVITY IN MAMMALS | ADVANCED SYNTECH, LLC | 2002-10-08 | — | — | US | disclosed |
| WO-2002053546-A1 | HETEROCYCLE DERIVATIVES AS PPAR-GAMMA AGONISTS | ADVANCED SYNTECH, LLC (US) | 2002-07-11 | — | — | WO | disclosed |