Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.67 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10242647 | 0.92 | SYK (0.67) | SYKKDRMAPK8MAPK9CDK1 | |
| SCHEMBL15161209 | 0.91 | SYK (0.67) | SYKMAPK8MAPK9JAK1JAK3 | |
| SCHEMBL10242654 | 0.87 | SYK (0.73) | SYKMAPK8MAPK9JAK3EGFR | |
| SCHEMBL10241915 | 0.87 | SYK (0.73) | SYKMAPK8MAPK9JAK3EGFR | |
| SCHEMBL10241920 | 0.85 | SYK (0.58) | SYKMAPK8MAPK9CDK1JAK1 | |
| SCHEMBL764179 | 0.82 | SYK (0.68) | SYK | |
| SCHEMBL763458 | 0.82 | SYK (0.66) | SYKMAPK8MAPK9 | |
| SCHEMBL10244483 | 0.81 | SYK (0.71) | SYKKDRMAPK8MAPK9CDK1 | |
| SCHEMBL764198 | 0.81 | SYK (0.69) | SYKMAPK8MAPK9 | |
| SCHEMBL13624765 | 0.81 | SYK (0.69) | SYKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138339-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20090318407-A1 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318407-A1 | Inhibitors of protein kinases | SYK, BTK, JAK1 | SYK 1/4885KDR 585/4885MAPK8 420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.