Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGH | Q92820 | 2/20 | 0.56 |
| ▸ | NAALAD2 | Q9Y3Q0 | 3/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.47 |
| ▸ | CPA3 | P15088 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7642260 | 0.88 | GGH (0.57) | GGHNAALAD2FOLH1CPA3GAA | |
| SCHEMBL1374224 | 0.81 | GGH (0.65) | GGHNAALAD2FOLH1CPA3GAA | |
| SCHEMBL1374225 | 0.81 | GGH (0.65) | GGHNAALAD2FOLH1CPA3GAA | |
| SCHEMBL2368762 | 0.77 | GGH (0.57) | GGHNAALAD2FOLH1CPA3GAA | |
| SCHEMBL2368758 | 0.77 | GGH (0.59) | GGHNAALAD2FOLH1CPA3GAA | |
| SCHEMBL2368764 | 0.77 | GGH (0.59) | GGHNAALAD2FOLH1CPA3GAA | |
| SCHEMBL8649767 | 0.77 | GGH (0.44) | GGHNAALAD2FOLH1 | |
| SCHEMBL7608262 | 0.74 | GGH (0.50) | GGHFOLH1MMP9 | |
| SCHEMBL5060126 | 0.73 | GGH (0.55) | GGHNAALAD2FOLH1CPA3 | |
| SCHEMBL5059860 | 0.73 | GGH (0.62) | GGHNAALAD2FOLH1CPA3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413948-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | GUILFORD PHARMACEUTICALS INC. | 2002-07-02 | — | — | US | disclosed |