Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 2/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.59 |
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | CCND3 | P30281 | 2/20 | 0.59 |
| ▸ | CDK9 | P50750 | 2/20 | 0.59 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.59 |
| ▸ | BRD4 | O60885 | 17/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | JAK1 | P23458 | 1/20 | 0.54 |
| ▸ | BRD2 | P25440 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.54 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13072102 | 0.84 | BRD4 (0.61) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL270128 | 0.83 | CCNK (0.71) | CCNKCCNA2CDK2CCND3CDK9 | |
| Hydrochloric Acid SCHEMBL264699 | 0.82 | CCNK (0.70) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL302717 | 0.81 | AURKB (0.55) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL29793817 | 0.81 | EGFR (0.69) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL270085 | 0.81 | EGFR (0.69) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL303725 | 0.80 | AXL (0.47) | BRD4EGFRJAK2 | |
| Hydrochloric Acid SCHEMBL264814 | 0.80 | EGFR (0.68) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL271215 | 0.78 | BRD4 (0.62) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL265485 | 0.78 | BRD4 (0.72) | CCNKCCNA2CDK2CCND3CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138199-B2 | Use of bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20090275582-A1 | Bi-Aryl Meta-Pyrimidine Inhibitors of Kinases | IMPACT BIOMEDICINES, INC. | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275582-A1 | Bi-Aryl Meta-Pyrimidine Inhibitors of Kinases | JAK2, TYK2, JAK3 | CCNK 189/4885CCNA2 836/4885CDK2 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.