Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 4/20 | 0.39 |
| ▸ | HRH1 | P35367 | 4/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.35 |
| ▸ | ITK | Q08881 | 2/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7642572 | 0.86 | MCHR1 (0.37) | HRH2HRH1HRH3MCHR1CCR3 | |
| SCHEMBL7250778 | 0.83 | KCNA5 (0.45) | KCNA5DRD2DRD4DRD3HRH2 | |
| SCHEMBL7661257 | 0.82 | HRH3 (0.42) | KCNA5DRD2DRD4DRD3HRH2 | |
| SCHEMBL7246408 | 0.80 | HRH2 (0.41) | KCNA5DRD2DRD4DRD3HRH2 | |
| SCHEMBL6095849 | 0.78 | GRIN2B (0.61) | KCNA5CCR6GRIN2BKMT2A | |
| SCHEMBL7243006 | 0.75 | HRH3 (0.44) | HRH2HRH1HRH3MCHR1MEN1 | |
| SCHEMBL7252505 | 0.75 | CYP2D6 (0.41) | DRD2DRD3HRH2HRH1HRH3 | |
| SCHEMBL7242815 | 0.74 | CCR3 (0.41) | DRD2DRD3HRH2HRH1HRH3 | |
| SCHEMBL7245194 | 0.73 | HRH3 (0.39) | KCNA5DRD2DRD4DRD3HRH2 | |
| SCHEMBL7248205 | 0.73 | CYP2D6 (0.39) | DRD2DRD3HRH2HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244631-A1 | NEW AZABICYCLOOCTANE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047893-A1 | NEW AZABICYCLOOCTANE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2001-07-05 | — | — | WO | disclosed |