SCHEMBL7647450

SCHEMBL7647450

C[C@H]1[C@H](NC(=O)c2ccc(-c3ccc(OCc4cccc(F)c4)cc3)s2)C2CCN1CC2

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.47
CHRNA7 P36544 3/20 0.47
CHRNA4 P43681 3/20 0.47
NR4A2 P43354 1/20 0.44
MAOB P27338 9/20 0.43
MAOA P21397 7/20 0.43
F10 P00742 1/20 0.42
ESRRG P62508 1/20 0.42
HDAC3 O15379 1/20 0.42
ABL1 P00519 1/20 0.42
EGFR P00533 1/20 0.42
ERBB2 P04626 1/20 0.42
INSR P06213 1/20 0.42
PDGFRB P09619 1/20 0.42
CDK2 P24941 1/20 0.42
PLK1 P53350 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7060487 0.91 NR4A2 (0.55) CHRNB2CHRNA7CHRNA4NR4A2ESRRG
SCHEMBL7062314 0.85 CHRNA7 (0.55) CHRNB2CHRNA7CHRNA4NR4A2F10
SCHEMBL7062163 0.83 CHRNA7 (0.49) CHRNB2CHRNA7CHRNA4NR4A2HDAC3
Hydrochloric Acid SCHEMBL7587770 0.82 CHRNA7 (0.61) CHRNA7MAOBMAOA
SCHEMBL7059368 0.81 KDM4E (0.56) CHRNB2CHRNA7CHRNA4ESRRGKCNH2
SCHEMBL7064066 0.79 CHRNA7 (0.61) CHRNB2CHRNA7CHRNA4HDAC1
SCHEMBL7062230 0.78 ESRRG (0.53) CHRNB2CHRNA7CHRNA4ESRRG
SCHEMBL7064093 0.78 CHRNA7 (0.50) CHRNB2CHRNA7CHRNA4ESRRG
SCHEMBL7060459 0.78 HDAC6 (0.50) CHRNB2CHRNA7CHRNA4HDAC6
SCHEMBL7128321 0.78 USP30 (0.44) CHRNB2CHRNA7CHRNA4NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6492385-B2 CENTRAL NERVOUS SYSTEM DISORDERS PHARMACIA & UPJOHN COMPANY 2002-12-10 US disclosed