Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 19/20 | 0.71 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7648434 | 0.89 | DRD4 (0.89) | DRD4DRD2 | |
| Oxalic Acid SCHEMBL7651264 | 0.89 | DRD4 (0.91) | DRD4DRD2SIGMAR1 | |
| Oxalic Acid SCHEMBL7644553 | 0.86 | DRD4 (0.90) | DRD4DRD2 | |
| Oxalic Acid SCHEMBL6160267 | 0.85 | DRD4 (0.88) | DRD4DRD2 | |
| Oxalic Acid SCHEMBL6161304 | 0.85 | DRD4 (0.88) | DRD4DRD2 | |
| Oxalic Acid SCHEMBL6162619 | 0.85 | DRD4 (0.88) | DRD4DRD2 | |
| Oxalic Acid SCHEMBL6161557 | 0.84 | DRD4 (0.89) | DRD4DRD2 | |
| Oxalic Acid SCHEMBL6165259 | 0.83 | DRD4 (0.88) | DRD4DRD2 | |
| SCHEMBL7650342 | 0.83 | DRD4 (1.00) | DRD4DRD2SIGMAR1 | |
| Oxalic Acid SCHEMBL6163601 | 0.83 | DRD4 (0.89) | DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479491-B1 | USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, ESPECIALLY PSYCHOTIC DISORDERS SUCH AS SCHIZOPHRENIA | NEUROSEARCH A/S (DK) | 2002-11-12 | — | — | US | disclosed |
| US-6207662-B1 | USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, PSYCHOTIC DISORDERS SUCH AS SCHIZOPHRENIA | NEUROSEARCH A/S (DK) | 2001-03-27 | — | — | US | disclosed |
| EP-0920423-A1 | DISUBSTITUTED MORPHOLINE, OXAZEPINE OR THIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE D4 RECEPTOR ANTAGONISTS | NEUROSEARCH A/S (DK) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998007710-A1 | DISUBSTITUTED MORPHOLINE, OXAZEPINE OR THIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE D4 RECEPTOR ANTAGONISTS | NEUROSEARCH A/S (DK) | 1998-02-26 | — | — | WO | disclosed |