⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1582044 | 1.00 | — | — | |
| Bromide SCHEMBL7624004 | 0.97 | — | — | |
| SCHEMBL11312346 | 0.79 | — | — | |
| SCHEMBL10411235 | 0.75 | — | — | |
| SCHEMBL5139831 | 0.75 | — | — | |
| SCHEMBL1191294 | 0.75 | — | — | |
| SCHEMBL9302436 | 0.74 | — | — | |
| SCHEMBL214833 | 0.72 | — | — | |
| SCHEMBL10596901 | 0.72 | — | — | |
| SCHEMBL6018532 | 0.69 | TSHR (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500811-B2 | PROPHYLAXIS AND THERAPY OF DISORDERS IN THE COURSE OF WHICH AN INCREASED ACTIVITY OF MATRIX-DEGRADING ENZYMES IS INVOLVED; THESE INCLUDE DEGENERATIVE JOINT DISORDERS SUCH AS OSTEOARTHROSES AND DISORDERS OF CONNECTIVE TISSUE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-12-31 | — | — | US | disclosed |
| US-20020082246-A1 | Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use | AVENTIS PHARMA DEUTSCHLAND GMBH. | 2002-06-27 | — | — | US | disclosed |
| US-6235727-B1 | ENZYME INHIBITORS; MUSCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-05-22 | — | — | US | disclosed |