Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650655 | 1.00 | EIF2AK2 (0.35) | EIF2AK2MEN1KMT2AALDH1A1 | |
| SCHEMBL5893604 | 0.89 | EIF2AK2 (0.47) | EIF2AK2ALDH1A1 | |
| SCHEMBL5893613 | 0.89 | EIF2AK2 (0.47) | EIF2AK2ALDH1A1 | |
| SCHEMBL12856375 | 0.89 | EIF2AK2 (0.47) | EIF2AK2ALDH1A1 | |
| SCHEMBL7655144 | 0.75 | EIF2AK2 (0.38) | EIF2AK2KMT2AALDH1A1 | |
| SCHEMBL7655140 | 0.75 | EIF2AK2 (0.38) | EIF2AK2KMT2AALDH1A1 | |
| SCHEMBL5893496 | 0.72 | EIF2AK2 (0.47) | EIF2AK2ALDH1A1 | |
| SCHEMBL5893487 | 0.72 | EIF2AK2 (0.47) | EIF2AK2ALDH1A1 | |
| SCHEMBL6619758 | 0.72 | EIF2AK2 (0.47) | EIF2AK2ALDH1A1 | |
| SCHEMBL4080527 | 0.70 | CES1 (0.44) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387919-B1 | Substituted oxindole derivatives as protein tyrosine kinase and as protein serine/threonine kinase inhibitors | GLAXO WELLCOME INC. | 2002-05-14 | — | — | US | claimed |