Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 10/20 | 0.43 |
| ▸ | F10 | P00742 | 10/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.43 |
| ▸ | F7 | P08709 | 4/20 | 0.43 |
| ▸ | PLAU | P00749 | 4/20 | 0.39 |
| ▸ | PLAT | P00750 | 4/20 | 0.39 |
| ▸ | PLG | P00747 | 3/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 5/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | F9 | P00740 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651340 | 0.89 | F2 (0.44) | F2F10PRSS1F7PLAU | |
| SCHEMBL7657667 | 0.88 | CA1 (0.46) | F2F10PRSS1F7PLAU | |
| SCHEMBL7651303 | 0.87 | F2 (0.46) | F2F10PRSS1F7PLAU | |
| SCHEMBL7844103 | 0.86 | F7 (0.53) | F2F10PRSS1F7PLG | |
| SCHEMBL7665961 | 0.84 | F2 (0.47) | F2F10PRSS1F7PLAU | |
| SCHEMBL7663707 | 0.82 | F10 (0.54) | F2F10PRSS1F7PLAU | |
| SCHEMBL7663325 | 0.81 | F10 (0.55) | F2F10PRSS1F7PLAU | |
| SCHEMBL7654537 | 0.79 | F7 (0.49) | F2F10PRSS1F7PLAU | |
| SCHEMBL7663117 | 0.78 | F10 (0.56) | F2F10PRSS1F7PLAU | |
| SCHEMBL7653335 | 0.78 | F7 (0.58) | F2F10PRSS1F7PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358960-B1 | FOR THERAPY OF INTRAVASCULAR COAGULATION, CORONARY THROMBOSIS, CEREBRAL INFARCTION, CEREBRAL EMBOLISM, TRANSIENT ISCHEMIC ATTACK, CEREBROVASCULAR DISORDERS, PULMONARY VASCULAR DISEASES, DEEP VENOUS THROMBOSIS, ETC. | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| EP-1078917-A1 | AMIDINO DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-02-28 | — | — | EP | disclosed |