Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PTPRA | P18433 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655136 | 0.78 | CYP2D6 (0.39) | TSHRHTTGAAALDH1A1CYP1A2 | |
| SCHEMBL7644687 | 0.75 | HDAC1 (0.38) | TSHRPOLBPTPRAALDH1A1HSD17B10 | |
| SCHEMBL7650927 | 0.74 | TSHR (0.41) | TSHRHTTGAAALDH1A1KMT2A | |
| SCHEMBL28679009 | 0.68 | POLB (0.44) | TSHRPOLBPTPRAGAAALDH1A1 | |
| SCHEMBL4461877 | 0.66 | SLC6A2 (0.48) | TSHRPOLBHTTALDH1A1CYP1A2 | |
| SCHEMBL15348824 | 0.65 | TSHR (0.50) | TSHRPOLBHTTALDH1A1CYP1A2 | |
| SCHEMBL4953717 | 0.65 | POLB (0.44) | TSHRPOLBPTPRAGAAALDH1A1 | |
| SCHEMBL4953723 | 0.65 | POLB (0.44) | TSHRPOLBPTPRAGAAALDH1A1 | |
| SCHEMBL935444 | 0.64 | HTT (0.54) | TSHRPOLBHTTALDH1A1NPC1 | |
| SCHEMBL7904906 | 0.64 | KMT2A (0.54) | TSHRPOLBHTTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002515040-A | — | — | 2002-05-21 | — | — | JP | claimed |
| EP-0954295-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997048409-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |