Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 5/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764485 | 0.89 | BDKRB1 (0.61) | BDKRB1MAPK14MAPK11CYP3A4HTT | |
| SCHEMBL764429 | 0.88 | BDKRB1 (0.58) | BDKRB1MAPK14CYP3A4HTTLMNA | |
| SCHEMBL764458 | 0.88 | BDKRB1 (0.64) | BDKRB1MAPK14MAPK11CYP3A4LMNA | |
| SCHEMBL764461 | 0.88 | BDKRB1 (0.61) | BDKRB1MAPK14CYP3A4HTTLMNA | |
| SCHEMBL765553 | 0.88 | BDKRB1 (0.58) | BDKRB1MAPK14MAPK11CYP3A4HTT | |
| SCHEMBL765538 | 0.88 | BDKRB1 (0.58) | BDKRB1MAPK14CYP3A4HTTLMNA | |
| SCHEMBL764413 | 0.88 | BDKRB1 (0.64) | BDKRB1MAPK14MAPK11CYP3A4HTT | |
| SCHEMBL10121331 | 0.87 | BDKRB1 (0.60) | BDKRB1MAPK14MAPK11CYP3A4HTT | |
| SCHEMBL13904092 | 0.87 | BDKRB1 (0.51) | BDKRB1MAPK14MAPK11SMN1; SMN2CNR1 | |
| SCHEMBL12239067 | 0.87 | BDKRB1 (0.60) | BDKRB1MAPK14MAPK11CYP3A4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188254-B1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2009027450-A1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-03-05 | — | — | WO | disclosed |