Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TYR | P14679 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1422649 | 0.80 | BTK (0.44) | KDM4EALDH1A1HPGDMAPK13MAPK12 | |
| SCHEMBL11169092 | 0.79 | AURKA (0.49) | KDM4ETP53NPC1RAB9AMAPT | |
| SCHEMBL5331158 | 0.75 | MAPT (0.51) | ALDH1A1HPGDMAPK13MAPK12MAPK11 | |
| SCHEMBL3029624 | 0.72 | GSK3B (0.30) | KDM4E | |
| SCHEMBL2556371 | 0.71 | TYR (0.43) | KDM4EALDH1A1HPGDTYRMAPK13 | |
| SCHEMBL15730025 | 0.70 | BTK (0.51) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL28767295 | 0.68 | TNKS2 (0.44) | KDM4EALDH1A1HPGDMAPK1CHEK2 | |
| SCHEMBL13160197 | 0.66 | HDAC3 (0.65) | KDM4EALDH1A1HPGDHDAC6HDAC3 | |
| SCHEMBL3333987 | 0.66 | NPC1 (0.68) | KDM4EALDH1A1HPGDHDAC6HDAC3 | |
| SCHEMBL3457617 | 0.65 | TYR (0.86) | KDM4EALDH1A1TYRMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1211370-C | Imidazole derivatives with biphenylsulfonyl substituents, process for their preparation and their use as pharmaceuticals or diagnostic agents | AVENTIS PHARMA GMBH (DE) | 2005-07-20 | — | — | CN | disclosed |
| US-6369236-B1 | DRUG FOR MEDICAL DIAGNOSIS ANTIARRHYTHMIC PROPRIETIES AND CONTAIN A CARDIOPROTECTIVE COMPOUND. THEY CAN PREVENTIVELY INHIBIT OR STRONGLY REDUCE PATHOPHYSIOLOGIC PROCESSES UPON OCCURRENCE OF ISCHEMIC INJURIES, ESPECIALLY ISCHEMIC CARDIAC | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-09 | — | — | US | disclosed |
| CN-1309645-A | Imidazole derivatives with biphenylsulfonyl substituents, process for their preparation and their use as pharmaceuticals or diagnostic agents | AVENTIS PHARMA GMBH (DE) | 2001-08-22 | — | — | CN | disclosed |
| EP-1097141-A1 | IMIDAZOLE DERIVATIVES WITH BIPHENYLSULFONYL SUBSTITUTION, METHOD FOR PREPARING THEM AND THEIR USE AS A DRUG OR DIAGNOSTIC AGENT | Aventis Pharma Deutschland GmbH (DE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000003996-A1 | IMIDAZOLE DERIVATIVES WITH BIPHENYLSULFONYL SUBSTITUTION, METHOD FOR PREPARING THEM AND THEIR USE AS A DRUG OR DIAGNOSTIC AGENT | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |