Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5619882 | 0.84 | MAPK14 (0.59) | MAPK14MAPK11 | |
| SCHEMBL4592699 | 0.84 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4982773 | 0.82 | MAPK14 (0.61) | MAPK14MAPK11 | |
| SCHEMBL4986365 | 0.82 | MAPK14 (0.61) | MAPK14MAPK11 | |
| SCHEMBL4987749 | 0.82 | MAPK14 (0.58) | MAPK14MAPK11 | |
| SCHEMBL4985137 | 0.82 | MAPK14 (0.61) | MAPK14MAPK11 | |
| SCHEMBL6947142 | 0.82 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4593758 | 0.79 | MAPK13 (0.82) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8323305 | 0.79 | MAPK13 (0.67) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4984681 | 0.78 | MAPK14 (0.62) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6489325-B1 | INHIBITORS OF CSBP/P38, ONE OF SEVERAL KINASES INVOLVED IN A STRESS-RESPONSE SIGNAL TRANSDUCTION, DECREASE THE SYNTHESIS OF A WIDE VARIETY OF PRO-INFLAMMATORY PROTEINS INCLUDING, IL-6, IL-8, GM-CSF, AND COX-2 | SMITHKLINE BEECHAM CORPORATION | 2002-12-03 | — | — | US | disclosed |