Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 6/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13540996 | 0.88 | GSR (0.45) | GSRCHRM2CYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL31226482 | 0.87 | GSR (0.40) | GSRCHRM2CYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL114055 | 0.87 | GSR (0.40) | GSRCHRM2CYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL30635465 | 0.83 | CHRM2 (0.43) | GSRCHRM2CYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL27088752 | 0.82 | GSR (0.41) | GSRCHRM2CYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL29998684 | 0.82 | GSR (0.41) | GSRCHRM2CYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL28206269 | 0.79 | ATM (0.51) | GSRALDH1A1KDM4EPOLB | |
| SCHEMBL29998956 | 0.78 | CYP3A4 (0.48) | GSRPDCD1CD274KDM4E | |
| SCHEMBL29870183 | 0.78 | CYP1A2 (0.74) | CHRM2CYP1A2CYP2D6SMN1; SMN2ALDH1A1 | |
| SCHEMBL4051279 | 0.78 | CYP1A2 (0.74) | CHRM2CYP1A2CYP2D6SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| EP-1001944-A1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-05-24 | — | — | EP | claimed |
| WO-1999003844-A1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1999-01-28 | — | — | WO | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |
| EP-1001944-A1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999003844-A1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1999-01-28 | — | — | WO | disclosed |