Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 14/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.35 |
| ▸ | HTR3B | O95264 | 5/20 | 0.35 |
| ▸ | HTR3A | P46098 | 5/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6829677 | 0.86 | CHRNA7 (0.43) | CHRNA7CHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL6805064 | 0.86 | CHRNA7 (0.43) | CHRNA7CHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL7063496 | 0.83 | CHRNA7 (0.40) | CHRNA7CHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL7059206 | 0.82 | CHRNA7 (0.49) | CHRNA7CHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL7060995 | 0.82 | CHRNA7 (0.39) | CHRNA7CHRNB2CHRNA4HTR3AKMT2A | |
| SCHEMBL7064022 | 0.81 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL7064115 | 0.81 | CHRNA7 (0.40) | CHRNA7CHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL7060781 | 0.81 | KMT2A (0.47) | CHRNA7CHRNB2CHRNA4RAB9AHPGD | |
| SCHEMBL7063201 | 0.81 | CHRNA7 (0.41) | CHRNA7CHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL7062090 | 0.80 | CHRNA7 (0.38) | CHRNA7CHRNB2CHRNA4HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492385-B2 | CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY | 2002-12-10 | — | — | US | claimed |