Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653389 | 0.99 | P2RX4 (0.60) | P2RX4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL7652274 | 0.95 | P2RX4 (0.61) | P2RX4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL7648583 | 0.89 | HDAC1 (0.59) | P2RX4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL6266030 | 0.87 | P2RX4 (0.72) | P2RX4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL17242769 | 0.85 | P2RX4 (0.57) | P2RX4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL17241700 | 0.83 | HDAC1 (0.60) | P2RX4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL17241691 | 0.83 | P2RX4 (0.54) | P2RX4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL6466889 | 0.82 | P2RX4 (0.64) | P2RX4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL12963694 | 0.81 | HDAC1 (0.67) | P2RX4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL8352700 | 0.81 | P2RX4 (0.67) | P2RX4HDAC1HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |