Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.68 |
| ▸ | DRD1 | P21728 | 6/20 | 0.63 |
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7596672 | 0.84 | PRCP (0.69) | PRCPDRD1DRD2HTR2A | |
| SCHEMBL25604565 | 0.81 | PRCP (1.00) | PRCPDRD1DRD2 | |
| SCHEMBL8415128 | 0.81 | PRCP (1.00) | PRCPDRD1DRD2 | |
| SCHEMBL13928812 | 0.81 | PRCP (1.00) | PRCPDRD1DRD2 | |
| SCHEMBL28942533 | 0.80 | PRCP (0.64) | PRCPDRD1DRD2CA1CA2 | |
| SCHEMBL29783557 | 0.80 | PRCP (0.64) | PRCPDRD1DRD2CA1CA2 | |
| Iodide SCHEMBL27518895 | 0.80 | PRCP (0.97) | PRCPDRD1DRD2 | |
| SCHEMBL28759507 | 0.79 | PRCP (0.67) | PRCPDRD1DRD2CA1CA2 | |
| SCHEMBL29783565 | 0.79 | PRCP (0.67) | PRCPDRD1DRD2CA1CA2 | |
| SCHEMBL21444628 | 0.78 | DRD1 (0.80) | PRCPDRD1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492378-B1 | Substituted isoquinoline derivatives and their use as anticonvulsivants | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-12-10 | — | — | US | disclosed |
| EP-1104404-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009486-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSIVANTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-24 | — | — | WO | disclosed |