Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.34 |
| ▸ | SGK1 | O00141 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.33 |
| ▸ | GABRP | O00591 | 3/20 | 0.33 |
| ▸ | GABRD | O14764 | 3/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.33 |
| ▸ | GABRE | P78334 | 3/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.33 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.33 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981190 | 1.00 | PPARA (0.37) | PPARACTSSGABRA1GABRG2GABRB3 | |
| SCHEMBL7847415 | 0.87 | PPARA (0.38) | PPARACTSSGABRA1GABRG2GABRB3 | |
| SCHEMBL7847407 | 0.87 | PPARA (0.38) | PPARACTSSGABRA1GABRG2GABRB3 | |
| SCHEMBL8012586 | 0.74 | GNRHR (0.49) | — | |
| SCHEMBL7858393 | 0.74 | GNRHR (0.49) | — | |
| SCHEMBL7977562 | 0.73 | GNRHR (0.51) | — | |
| SCHEMBL7977559 | 0.73 | GNRHR (0.51) | — | |
| SCHEMBL7643917 | 0.70 | GNRHR (0.42) | — | |
| SCHEMBL7643913 | 0.70 | GNRHR (0.42) | — | |
| SCHEMBL8479692 | 0.70 | GNRHR (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067930-A4 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6228867-B1 | 2-PHENYL-PYRROLO(2,3-B)PYRIDINE DERIVATIVES FOR TREATING UROGENITAL AND SLEEP DISORDERS; ANTICARCINOGENIC AGENTS; BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-05-08 | — | — | US | disclosed |
| EP-1067930-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 2001-01-17 | — | — | EP | disclosed |
| EP-1066285-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 2001-01-10 | — | — | EP | disclosed |
| US-6110931-A | FOR PREGNANCY PROPHYLAXIS AND TREATMENT OF GLANDULAR DISORDERS, HORMONE DEFICIENCY DISORDERS, GASTROINTESTINAL DISORDERS, GROWTH DISORDERS | MERCK & CO., INC. (US) | 2000-08-29 | — | — | US | disclosed |
| US-6077847-A | ADMINISTERING A SUBSTITUTED INDOLE COMPOUND TO THE PATIENTS FOR THE TREATMENT OF A VARIETY OF SEX-HORMONE RELATED AND OTHER CONDITIONS IN BOTH MEN AND WOMEN | MERCK & CO., INC. (US) | 2000-06-20 | — | — | US | disclosed |
| US-6025366-A | Antagonists of gonadotropin releasing hormone | MERCK & CO., INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-5998432-A | SEXUAL DISORDERS | MERCK & CO., INC. (US) | 1999-12-07 | — | — | US | disclosed |
| US-5985892-A | USEFUL FOR THE TREATMENT OF A VARIETY OF SEX-HORMONE RELATED AND OTHER CONDITIONS IN BOTH MEN AND WOMEN; PREVENTING PREGNANCY; TREATING LUPUS ERYTHEMATOSIS, IRRITABLE BOWEL SYNDROME, PREMENSTRUAL SYNDROME, HIRSUTISM, SHORT STATURE OR A | MERCK & CO., LTD. (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1999051232-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1999-10-14 | — | — | WO | disclosed |
| WO-1999051595-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1999-10-14 | — | — | WO | disclosed |