Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.43 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | PPIA | P62937 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7660169 | 0.92 | PTGER1 (0.44) | PPARGMAPTPTGER1HPGDTP53 | |
| SCHEMBL6308035 | 0.87 | MEN1 (0.49) | PPARGPDE2APDE10AMAPT | |
| SCHEMBL6303779 | 0.87 | PPARG (0.46) | PPARGPDE2APDE10AMAPTALDH1A1 | |
| SCHEMBL6308856 | 0.84 | PPARG (0.52) | PPARGPDE2APDE10AKDM4EALDH1A1 | |
| SCHEMBL6169005 | 0.82 | PDE2A (0.55) | PPARGPDE2APDE10AHTTHSD17B10 | |
| SCHEMBL6172705 | 0.81 | MEN1 (0.52) | PDE2AMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL6301641 | 0.80 | PDE2A (0.51) | PPARGPDE2APDE10AHTTHSD17B10 | |
| SCHEMBL7597439 | 0.80 | PTGER1 (0.47) | PTGER1 | |
| SCHEMBL6301170 | 0.80 | PPARG (0.52) | PPARGPDE2APDE10AMAPTKDM4E | |
| SCHEMBL7654594 | 0.80 | PPARG (0.52) | PPARGPDE2APDE10AHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420409-B1 | GLUCOSE TOLERANCE, DIABETES,INSULIN RESISTANCE, POLYCYSTIC OVARY SYNDROME, HYPERLIPIDEMIA, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS, HYPERGLYCEMIA, HYPERTENSION, STENOCARDIA, PULMONARY HYPERTENSION, CONGESTIVE HEART FAILURE, | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1020452-A1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |