Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | CTSV | O60911 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | PPIA | P62937 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544956 | 0.88 | MEN1 (0.61) | MEN1KMT2AMAPTCYP19A1CYP11B1 | |
| SCHEMBL371728 | 0.86 | MEN1 (0.70) | MEN1KMT2AMAPTCYP19A1CYP11B1 | |
| SCHEMBL31418722 | 0.86 | MEN1 (0.70) | MEN1KMT2AMAPTCYP19A1CYP11B1 | |
| SCHEMBL4031443 | 0.85 | MEN1 (0.49) | MEN1KMT2AMAPTCYP19A1CYP11B1 | |
| SCHEMBL7825518 | 0.84 | MEN1 (0.67) | MEN1KMT2AMAPTCYP19A1CYP11B1 | |
| SCHEMBL371744 | 0.82 | MEN1 (0.65) | MEN1KMT2AMAPTCYP19A1CYP11B1 | |
| SCHEMBL15814442 | 0.82 | MEN1 (0.65) | MEN1KMT2AMAPTCYP19A1CYP11B1 | |
| SCHEMBL8808139 | 0.82 | MEN1 (0.69) | MEN1KMT2AMAPTCYP19A1CYP11B1 | |
| SCHEMBL31071620 | 0.82 | MEN1 (0.65) | MEN1KMT2AMAPTCYP19A1CYP11B1 | |
| SCHEMBL30354856 | 0.82 | MEN1 (0.69) | MEN1KMT2AMAPTCYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372754-B1 | DRUGS FOR TREATMENT OR PREVENTION OF DEPRESSION, ANXIETY, PAIN, INFLAMMATION, MIGRAINE, EMESIS OR POSTHERPIC NEURALGIA. | MERCK SHARP & DOHME LTD. | 2002-04-16 | — | — | US | disclosed |
| EP-1161419-A1 | SPIROCYCLIC KETONES AND THEIR USE AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2001-12-12 | — | — | EP | disclosed |
| US-6172077-B1 | TACHYKININ INHIBITORS; ANALGESICS, ANTIINFLAMMATORY AGENTS, ANTIEMETICS; NEURALGIA, HEADACHES | MERCK SHARP & DOHME LTD. (GB) | 2001-01-09 | — | — | US | disclosed |
| WO-2000047562-A1 | SPIROCYCLIC KETONES AND THEIR USE AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2000-08-17 | — | — | WO | disclosed |
| EP-0977758-A1 | SPIRO-AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049170-A1 | SPIRO-AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1998-11-05 | — | — | WO | disclosed |