Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.68 |
| ▸ | HTR2B | P41595 | 8/20 | 0.68 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30794779 | 0.89 | HTR2C (0.70) | HTR2CHTR2BNTSR1ERBB2NR1I2 | |
| SCHEMBL5801524 | 0.89 | HTR2C (0.70) | HTR2CHTR2BNTSR1ERBB2NR1I2 | |
| Hydrochloric Acid SCHEMBL7659046 | 0.86 | HTR2C (0.66) | HTR2CHTR2BNTSR1ERBB2PLK4 | |
| SCHEMBL7660298 | 0.85 | HTR2B (0.76) | HTR2CHTR2BNTSR1PLK4CHEK1 | |
| SCHEMBL7655395 | 0.84 | HTR2C (0.66) | HTR2CHTR2BNTSR1RAB9ASMN1; SMN2 | |
| SCHEMBL7660018 | 0.81 | HTR2C (1.00) | HTR2CHTR2BNTSR1PLK4CHEK1 | |
| SCHEMBL7369055 | 0.75 | HTR2C (0.69) | HTR2CHTR2BPLK4CHEK1PDPK1 | |
| SCHEMBL8944851 | 0.75 | HTR2C (0.86) | HTR2CHTR2BRAB9ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL7656179 | 0.74 | HTR2C (0.98) | HTR2CHTR2BPLK4CHEK1PDPK1 | |
| SCHEMBL7452301 | 0.72 | NPC1 (0.72) | HTR2CHTR2BPLK4CHEK1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | claimed |
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | disclosed |