Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 17/20 | 0.49 |
| ▸ | RARG | P13631 | 17/20 | 0.49 |
| ▸ | RARA | P10276 | 13/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655988 | 0.88 | KMT2A (0.44) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9817651 | 0.86 | RARB (0.53) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8659339 | 0.83 | NPC1 (0.36) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7655238 | 0.82 | RARB (0.42) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7650779 | 0.81 | — | — | |
| SCHEMBL7650875 | 0.80 | MAP3K14 (0.31) | — | |
| SCHEMBL6037049 | 0.80 | RARB (0.67) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7656508 | 0.80 | CYP3A4 (0.58) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8671496 | 0.79 | KMT2A (0.45) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7143159 | 0.79 | RARB (0.55) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344463-B1 | SKIN DISORDERS, ACNE | ALLERGAN SALES, INC. | 2002-02-05 | — | — | US | disclosed |
| EP-0636127-B1 | Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity | ALLERGAN INC (US) | 2001-04-04 | — | — | EP | disclosed |
| US-6090826-A | Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity | ALLERGAN SALES, INC. (US) | 2000-07-18 | — | — | US | disclosed |
| US-5663347-A | REGULATORS OF CELL PROLIFERATION AND DIFFERENTIATION; TREATMENT OF SKIN DISORDERS; ANTICARCINOGNIC AGENTS | ALLERGAN (US) | 1997-09-02 | — | — | US | disclosed |
| US-5468879-A | Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity | ALLERGAN, INC. (US) | 1995-11-21 | — | — | US | disclosed |
| EP-0636127-A1 | DISUBSTITUTED ACETYLENES BEARING HETEROBICYCLIC GROUPS AND HETEROAROMATIC OR PHENYL GROUPS HAVING RETINOID LIKE ACTIVITY | ALLERGAN, INC. (US) | 1995-02-01 | — | — | EP | disclosed |
| US-5264578-A | Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity | ALLERGAN, INC. (US) | 1993-11-23 | — | — | US | disclosed |
| WO-1993016068-A1 | DISUBSTITUTED ACETYLENES BEARING HETEROBICYCLIC GROUPS AND HETEROAROMATIC OR PHENYL GROUPS HAVING RETINOID LIKE ACTIVITY | ALLERGAN, INC. (US) | 1993-08-19 | — | — | WO | disclosed |