SCHEMBL7655033

SCHEMBL7655033

C=C(C1CC1)[C@]1(C(F)(F)F)O[C@@H](CCBr)C(=O)Nc2ccc(Cl)cc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP46A1 Q9Y6A2 5/20 0.38
HTR2A P28223 2/20 0.38
NR1I2 O75469 1/20 0.38
NR3C1 P04150 1/20 0.38
PGR P06401 1/20 0.38
ADRB1 P08588 1/20 0.38
ADORA3 P0DMS8 1/20 0.38
MAPT P10636 1/20 0.38
CNR1 P21554 1/20 0.38
SLC6A2 P23975 1/20 0.38
HTR2C P28335 1/20 0.38
MAPK1 P28482 1/20 0.38
AGTR1 P30556 1/20 0.38
CCKBR P32239 1/20 0.38
PPARG P37231 1/20 0.38
OPRK1 P41145 1/20 0.38
SLC6A3 Q01959 1/20 0.38
PDE4D Q08499 1/20 0.38
PDE3A Q14432 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4765863 0.78 CYP46A1 (0.54) CYP46A1HTR2ANR1I2NR3C1PGR
SCHEMBL4765852 0.78 CYP46A1 (0.54) CYP46A1HTR2ANR1I2NR3C1PGR
SCHEMBL7655679 0.75 CYP46A1 (0.64) CYP46A1HTR2ANR1I2NR3C1PGR
SCHEMBL7655039 0.75 HTR2A (0.55) CYP46A1HTR2ANR1I2NR3C1PGR
SCHEMBL7660040 0.74 PTGDR2 (0.41) ELOVL6MEN1KMT2A
SCHEMBL1079633 0.69 PDE7A (0.45) CYP46A1HTR2ANR1I2NR3C1PGR
SCHEMBL1046527 0.69 PDE7A (0.45) CYP46A1HTR2ANR1I2NR3C1PGR
SCHEMBL1152148 0.65 HTR2A (0.60) CYP46A1HTR2ANR1I2NR3C1PGR
SCHEMBL1152149 0.65 HTR2A (0.60) CYP46A1HTR2ANR1I2NR3C1PGR
SCHEMBL1152153 0.65 CYP46A1 (0.64) CYP46A1HTR2ANR1I2NR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6489320-B1 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR AND BENZOXAPINONE FOR TREATMENT OF HIV INFECTION BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-12-03 US disclosed
US-6140320-A FOR TREATING HIV(HUMAN IMMUNODEFICIENCY VIRUS) INFECTIONS DUPONT PHARMACEUTICALS COMPANY (US) 2000-10-31 US disclosed
EP-1009742-A1 5,5-DISUBSTITUTED-1,5-DIHYDRO-4,1-BENZOXAZEPIN-2(3H)-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS Du Pont Pharmaceuticals Company (US) 2000-06-21 EP disclosed
WO-1999011635-A1 5,5-DISUBSTITUTED-1,5-DIHYDRO-4,1-BENZOXAZEPIN-2(3H)-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1999-03-11 WO disclosed