Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 7/20 | 0.69 |
| ▸ | CXCR1 | P25024 | 4/20 | 0.69 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.65 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.54 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 4/20 | 0.49 |
| ▸ | CA1 | P00915 | 4/20 | 0.49 |
| ▸ | CA2 | P00918 | 4/20 | 0.49 |
| ▸ | CA9 | Q16790 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4587524 | 0.85 | CXCR2 (0.74) | CXCR2CXCR1CX3CR1CA12CA1 | |
| SCHEMBL6550665 | 0.82 | CXCR2 (1.00) | CXCR2CXCR1CX3CR1CA12CA1 | |
| SCHEMBL30515694 | 0.79 | CXCR2 (1.00) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL29372271 | 0.79 | CXCR2 (1.00) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL1535901 | 0.79 | CXCR2 (1.00) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL6564271 | 0.79 | CXCR2 (0.72) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL4586744 | 0.79 | CXCR2 (0.81) | CXCR2CXCR1CX3CR1CA12CA1 | |
| SCHEMBL5265360 | 0.78 | CXCR2 (0.61) | CXCR2CXCR1CX3CR1CA12CA1 | |
| SCHEMBL5447783 | 0.78 | CXCR2 (0.97) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL4588226 | 0.78 | CXCR2 (0.97) | CXCR2CXCR1CX3CR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500863-B1 | INTERLEUKIN BINDING INHIBITORS SUCH AS N-(2-HYDROXYL-3-AMINO SULFONYL-4-CHLOROPHENYL)-N'-(2-BROMOPHENYL)UREA, USED FOR PROPHYLAXIS OF CHEMOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION | 2002-12-31 | — | — | US | claimed |