Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 20/20 | 0.74 |
| ▸ | KIT | P10721 | 1/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.65 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.65 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654089 | 0.85 | PDGFRB (0.76) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL2278769 | 0.85 | PDGFRB (1.00) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL2924358 | 0.84 | PDGFRB (1.00) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL1028741 | 0.82 | PDGFRB (1.00) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL2912640 | 0.82 | PDGFRB (1.00) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL2922737 | 0.80 | PDGFRB (1.00) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL2921676 | 0.80 | PDGFRB (1.00) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL1028739 | 0.80 | PDGFRB (0.75) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL2919152 | 0.80 | PDGFRB (1.00) | PDGFRBKITFGFR1PDGFRAFGFR2 | |
| SCHEMBL2922621 | 0.80 | PDGFRB (1.00) | PDGFRBKITFGFR1PDGFRAFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423716-B1 | Nitrogenous heterocyclic compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-07-23 | — | — | US | disclosed |
| EP-1067123-A1 | NITROGENOUS HETEROCYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-01-10 | — | — | EP | disclosed |