SCHEMBL7657360

SCHEMBL7657360

CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4oc(-c5ccc(O)c(O)c5)c(O)c(=O)c4c3)cccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.50
HSD17B10 Q99714 3/20 0.50
MEN1 O00255 2/20 0.50
TP53 P04637 2/20 0.50
CYP3A4 P08684 2/20 0.50
MAPT P10636 2/20 0.50
CYP2C9 P11712 2/20 0.50
ALOX15 P16050 2/20 0.50
ALOX12 P18054 2/20 0.50
CDK2 P24941 2/20 0.50
MAPK1 P28482 2/20 0.50
RECQL P46063 2/20 0.50
KMT2A Q03164 2/20 0.50
CYP2D6 P10635 1/20 0.50
ST6GAL1 P15907 1/20 0.50
CYP2C19 P33261 1/20 0.50
EDNRA P25101 7/20 0.48
BRD4 O60885 1/20 0.47
HDAC1 Q13547 1/20 0.44
SLCO2B1 O94956 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7665855 0.88 TP53 (0.54) KDM4EMEN1TP53CYP3A4MAPT
SCHEMBL7660305 0.78 MEN1 (0.53) KDM4EHSD17B10MEN1TP53CYP3A4
SCHEMBL7660698 0.78 MAPT (0.58) KDM4EHSD17B10MEN1TP53CYP3A4
SCHEMBL7656160 0.77 MEN1 (0.49) KDM4EHSD17B10MEN1TP53CYP3A4
SCHEMBL7657381 0.77 MEN1 (0.52) KDM4EHSD17B10MEN1TP53CYP3A4
SCHEMBL7665860 0.77 EDNRA (0.41) EDNRABRD4HDAC1
SCHEMBL7661882 0.76 MEN1 (0.52) KDM4EHSD17B10MEN1TP53CYP3A4
SCHEMBL7663357 0.76 KDM4E (0.52) KDM4EHSD17B10MEN1TP53CYP3A4
SCHEMBL7654780 0.75 KMT2A (0.55) KDM4EHSD17B10MEN1TP53CYP3A4
SCHEMBL7654319 0.75 MEN1 (0.51) KDM4EHSD17B10MEN1TP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6500846-B1 2-(4-CHLOROPHENYL)-7-METHOXYCHROMEN-4-ONE, AS CYCLIN-DEPENDENT KINASE INHIBITORS, USED AS ANTICARCINOGENIC AGENTS OR FOR PROPHYLAXIS OF NEURODEGENERATIVE DISEASE LG CHEMICAL, LTD. (KR) 2002-12-31 US claimed
EP-1109800-A1 NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE LG CHEMICAL LIMITED (KR) 2001-06-27 EP claimed
WO-2000012496-A1 NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE LG CHEMICAL LTD. (KR) 2000-03-09 WO claimed
US-6500846-B1 2-(4-CHLOROPHENYL)-7-METHOXYCHROMEN-4-ONE, AS CYCLIN-DEPENDENT KINASE INHIBITORS, USED AS ANTICARCINOGENIC AGENTS OR FOR PROPHYLAXIS OF NEURODEGENERATIVE DISEASE LG CHEMICAL, LTD. (KR) 2002-12-31 US disclosed
EP-1109800-A1 NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE LG CHEMICAL LIMITED (KR) 2001-06-27 EP disclosed
WO-2000012496-A1 NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE LG CHEMICAL LTD. (KR) 2000-03-09 WO disclosed