Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.45 |
| ▸ | OXTR | P30559 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5582563 | 0.80 | MCHR1 (0.58) | MCHR1HDAC3HDAC1HDAC2 | |
| SCHEMBL7678419 | 0.76 | MCHR1 (0.45) | MCHR1OXTRALDH1A1MAPTHPGD | |
| SCHEMBL5582718 | 0.73 | MCHR1 (0.71) | MCHR1 | |
| SCHEMBL5582702 | 0.69 | MCHR1 (0.82) | MCHR1HTR2C | |
| SCHEMBL28195590 | 0.68 | MCHR1 (0.52) | MCHR1HDAC3HDAC1HDAC2 | |
| SCHEMBL5582905 | 0.66 | PIKFYVE (0.33) | MCHR1 | |
| SCHEMBL5858450 | 0.64 | MAPT (0.59) | OXTRALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL5583904 | 0.62 | MCHR1 (0.69) | MCHR1HTR2C | |
| SCHEMBL5994627 | 0.62 | MCHR1 (1.00) | MCHR1HTR2C | |
| SCHEMBL2047793 | 0.60 | HPGD (0.63) | ALDH1A1MAPTHPGDKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218336-A2 | MELANIN CONCENTRATING HORMONE ANTAGONIST | Takeda Chemical Industries, Ltd. (JP) | 2002-07-03 | — | — | EP | claimed |
| WO-2001021577-A2 | MELANIN CONCENTRATING HORMONE ANTAGONIST | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-03-29 | — | — | WO | claimed |
| EP-1218336-A2 | MELANIN CONCENTRATING HORMONE ANTAGONIST | Takeda Chemical Industries, Ltd. (JP) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021577-A2 | MELANIN CONCENTRATING HORMONE ANTAGONIST | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-03-29 | — | — | WO | disclosed |