Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 14/20 | 0.78 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.78 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.78 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.78 |
| ▸ | HTR2A | P28223 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CASR | P41180 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657836 | 1.00 | CCR3 (0.78) | CCR3SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL6777868 | 0.89 | CCR3 (0.61) | CCR3SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL6773659 | 0.89 | CCR3 (0.61) | CCR3SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL6768391 | 0.88 | CCR3 (0.85) | CCR3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6768388 | 0.88 | CCR3 (0.85) | CCR3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7669574 | 0.88 | CCR3 (0.80) | CCR3SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL7669580 | 0.88 | CCR3 (0.80) | CCR3SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL6779886 | 0.88 | CCR3 (0.72) | CCR3SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL6779892 | 0.88 | CCR3 (0.72) | CCR3SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL7656364 | 0.88 | CCR3 (1.00) | CCR3SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441001-B1 | 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-08-27 | — | — | US | claimed |
| EP-1140833-A1 | 2-SUBSTITUTED-4-NITROGEN HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000035876-A1 | 2-SUBSTITUTED-4-NITROGEN HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-06-22 | — | — | WO | claimed |
| EP-1140833-A1 | 2-SUBSTITUTED-4-NITROGEN HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035876-A1 | 2-SUBSTITUTED-4-NITROGEN HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |