Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 3/20 | 0.66 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981493 | 0.96 | LSS (0.69) | LSSGBA1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6977387 | 0.86 | LSS (0.76) | LSSGBA1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6979382 | 0.85 | LSS (0.48) | LSSGBA1KDM4EMEN1KMT2A | |
| SCHEMBL8310420 | 0.84 | LSS (0.66) | LSSGBA1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL6969184 | 0.84 | LSS (0.54) | LSSGBA1ALDH1A1GAAGPR183 | |
| SCHEMBL6980618 | 0.83 | LSS (0.65) | LSSGBA1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6978604 | 0.82 | LSS (0.71) | LSSGBA1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6977537 | 0.82 | LSS (0.93) | LSSSMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL6981290 | 0.82 | LSS (0.67) | LSSSMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL6182258 | 0.80 | LSS (1.00) | LSSALDH1A1HSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6335341-B1 | ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2002-01-01 | — | — | US | disclosed |
| EP-1000057-A1 | PYRIDYL- AND PYRIMIDYL-HETEROCYCLIC COMPOUNDS INHIBITING OXIDO SQUALENE-CYCLASE | AstraZeneca UK Limited (GB) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999006395-A1 | PYRIDYL- AND PYRIMIDYL-HETEROCYCLIC COMPOUNDS INHIBITING OXIDO SQUALENE-CYCLASE | ZENECA LIMITED (GB) | 1999-02-11 | — | — | WO | disclosed |