Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 18/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | FPR3 | P25089 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.46 |
| ▸ | P2RY13 | Q9BPV8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993300 | 0.87 | P2RY12 (0.83) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL13768432 | 0.83 | P2RY12 (0.64) | P2RY12CYP2C9PGRADORA3CHRM1 | |
| SCHEMBL6999963 | 0.81 | P2RY12 (0.80) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL7474252 | 0.81 | P2RY12 (0.80) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL13764365 | 0.81 | P2RY12 (0.60) | P2RY12CYP2C9PGRADORA3CHRM1 | |
| SCHEMBL7506828 | 0.80 | P2RY12 (1.00) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL7504488 | 0.80 | P2RY12 (1.00) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL7513923 | 0.80 | P2RY12 (1.00) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL7657466 | 0.80 | P2RY12 (0.64) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL10074057 | 0.80 | P2RY12 (0.65) | P2RY12CYP2C9PGRADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369064-B1 | MYOCARDIAL INFARCTION AND UNSTABLE ANGINA; P2T-RECEPTOR ANTAGONISTS; ANTITHROMBOTIC AGENTS; 7-(SUBSTITUTED AMINO) -5-(THIO)-3H-1,2,3-TRIAZOLO(4,5-D)PYRIMIDIN-3-YL) -CYCLOPENTANECARBOXAMIDES | ASTRAZENECA AB (SE) | 2002-04-09 | — | — | US | disclosed |
| EP-1056749-A1 | NOVEL TRIAZOLO(4,5-d)PYRIMIDINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999041254-A1 | NOVEL TRIAZOLO(4,5-d)PYRIMIDINE COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |