SCHEMBL7658457

SCHEMBL7658457

Cn1cncc1C(O)(c1ccnc(Cl)c1)c1ccc2[nH]c(=O)cc(-c3cccc(Cl)c3)c2c1

nearest known ligand 0.84

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FNTA P49354 13/20 0.84
FNTB P49356 13/20 0.84
PGGT1B P53609 1/20 0.49
RORC P51449 6/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6169332 0.92 FNTA (0.84) FNTAFNTBPGGT1BRORC
SCHEMBL7815392 0.92 FNTA (0.84) FNTAFNTBPGGT1BRORC
SCHEMBL13529456 0.91 FNTA (1.00) FNTAFNTBPGGT1BRORC
Hydrochloric Acid SCHEMBL6010278 0.91 FNTA (0.90) FNTAFNTBPGGT1BRORC
SCHEMBL5657968 0.88 FNTA (0.87) FNTAFNTBPGGT1BRORC
SCHEMBL5659938 0.87 FNTA (0.85) FNTAFNTBPGGT1BRORC
Hydrochloric Acid SCHEMBL5656573 0.87 FNTA (0.85) FNTAFNTBPGGT1BRORC
SCHEMBL6170013 0.87 FNTA (0.82) FNTAFNTBPGGT1BRORC
SCHEMBL6010392 0.87 FNTA (0.76) FNTAFNTBPGGT1BRORC
SCHEMBL5658232 0.87 FNTA (0.84) FNTAFNTBPGGT1BRORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6388092-B2 ANTITUMOR AGENT PFIZER INC 2002-05-14 US disclosed