Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658482 | 1.00 | MEN1 (0.34) | MEN1KMT2AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL8705238 | 0.85 | KDM1A (0.33) | MEN1KMT2AAKT1 | |
| SCHEMBL8705237 | 0.85 | KDM1A (0.33) | MEN1KMT2AAKT1 | |
| SCHEMBL8700300 | 0.81 | KDM1A (0.39) | KDM4ELMNAAKT1 | |
| SCHEMBL8700303 | 0.81 | KDM1A (0.39) | KDM4ELMNAAKT1 | |
| SCHEMBL9702286 | 0.77 | AKT1 (0.39) | AKT1 | |
| SCHEMBL25240330 | 0.74 | SMN1; SMN2 (0.42) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL16394205 | 0.74 | SMN1; SMN2 (0.42) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL15667159 | 0.74 | SMN1; SMN2 (0.42) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL21456865 | 0.74 | SMN1; SMN2 (0.48) | MEN1KMT2AKDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846942-A | Cholecystokinin antagonists, their preparation and therapeutic use | WARNER-LAMBERT COMPANY (US) | 1998-12-08 | — | — | US | claimed |
| EP-0547178-A4 | NOVEL CHOLECYSTOKININ ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC USE | WARNER LAMBERT CO (US) | 1994-07-06 | — | — | EP | claimed |
| EP-0547178-A1 | NOVEL CHOLECYSTOKININ ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 1993-06-23 | — | — | EP | claimed |
| WO-1993003721-A1 | CHOLECYSTOKININ ANTAGONISTS USEFUL FOR TREATING DEPRESSION | WARNER-LAMBERT COMPANY (US) | 1993-03-04 | — | — | WO | claimed |
| WO-1992004045-A1 | NOVEL CHOLECYSTOKININ ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 1992-03-19 | — | — | WO | claimed |
| US-6492531-B1 | THE INVENTION CONCERNS CHOLECYSTOKININ (CCK) ANTAGONISTS USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS. ESPECIALLY USEFUL ARE CCK.SUB.B ANTAGONISTS SUCH AS CI-988. | WARNER-LAMBERT COMPANY | 2002-12-10 | — | — | US | disclosed |
| US-5217957-A | CHOLECYSTOKININ ANTAGONISTS USEFUL FOR TREATING DEPRESSION | WARNER-LAMBERT COMPANY (US) | 1993-06-08 | — | — | US | disclosed |
| WO-1993003721-A1 | CHOLECYSTOKININ ANTAGONISTS USEFUL FOR TREATING DEPRESSION | WARNER-LAMBERT COMPANY (US) | 1993-03-04 | — | — | WO | disclosed |