Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 4/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.49 |
| ▸ | ACACB | O00763 | 3/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14508997 | 0.81 | PARP15 (0.55) | PARP15PARP10GRM2FFAR1HPGD | |
| SCHEMBL31220925 | 0.80 | PARP10 (0.55) | PARP15PARP10GRM2ACACBFFAR1 | |
| SCHEMBL13439690 | 0.80 | FFAR1 (0.56) | PARP15PARP10MMP3FFAR1HPGD | |
| SCHEMBL10203545 | 0.80 | ACACB (0.59) | PARP15PARP10ACACBPARP2 | |
| SCHEMBL879115 | 0.80 | ACACB (0.59) | PARP15PARP10ACACBPARP2 | |
| SCHEMBL11941581 | 0.80 | PARP15 (0.54) | PARP15PARP10GRM2FFAR1HPGD | |
| SCHEMBL20969565 | 0.79 | PARP10 (0.56) | PARP15PARP10FFAR1PARP2 | |
| SCHEMBL14534755 | 0.79 | PARP15 (0.53) | PARP15PARP10GRM2FFAR1HPGD | |
| SCHEMBL12086465 | 0.79 | CYP4F2 (0.51) | PARP15PARP10MMP3ACACBFFAR1 | |
| SCHEMBL11049584 | 0.78 | PARP10 (0.55) | PARP15PARP10GRM2HPGDPARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951673-B1 | HETEROCYCLIC CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-09-05 | — | — | EP | disclosed |
| EP-1951690-B1 | HETEROCYCLIC CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-1954668-B9 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-1954668-B1 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2007062314-A2 | HETEROCYCLIC CETP INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007062308-A2 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | disclosed |