Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 18/20 | 0.57 |
| ▸ | PTPN2 | P17706 | 5/20 | 0.44 |
| ▸ | PTPRC | P08575 | 2/20 | 0.40 |
| ▸ | EPM2A | O95278 | 1/20 | 0.37 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7188007 | 0.88 | PTPN1 (0.59) | PTPN1PTPN2PTPRC | |
| SCHEMBL7188271 | 0.88 | PTPN1 (0.66) | PTPN1PTPN2PTPRCMEN1KMT2A | |
| SCHEMBL7183004 | 0.87 | PTPN1 (0.65) | PTPN1PTPN2PTPRCMEN1KMT2A | |
| SCHEMBL7659253 | 0.87 | PTPN1 (0.70) | PTPN1PTPN2PTPRC | |
| SCHEMBL7187515 | 0.84 | PTPN1 (0.57) | PTPN1PTPN2PTPRC | |
| SCHEMBL7595441 | 0.83 | PTPN1 (0.61) | PTPN1PTPN2PTPRCKMT2A | |
| SCHEMBL7599145 | 0.83 | PTPN1 (0.61) | PTPN1PTPN2PTPRC | |
| SCHEMBL7186859 | 0.83 | PTPN1 (0.56) | PTPN1PTPN2PTPRC | |
| SCHEMBL7193728 | 0.83 | PTPN1 (0.64) | PTPN1PTPN2PTPRC | |
| SCHEMBL7193731 | 0.83 | PTPN1 (0.64) | PTPN1PTPN2PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498151-B2 | PROTEIN TYROSINE PHOSPHATASES INHIBITORS, ESPECIALLY AS ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2002-12-24 | — | — | US | claimed |
| US-6498151-B2 | PROTEIN TYROSINE PHOSPHATASES INHIBITORS, ESPECIALLY AS ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2002-12-24 | — | — | US | disclosed |