Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.53 |
| ▸ | PDE4A | P27815 | 14/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7659290 | 1.00 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL7659295 | 1.00 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL6607854 | 0.93 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL6607847 | 0.93 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL4958570 | 0.93 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL29357646 | 0.93 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL7654261 | 0.91 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL7654256 | 0.91 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL4957740 | 0.91 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL6607325 | 0.86 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376535-B2 | PHOSPHODIESTERASE (PDE) INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-04-23 | — | — | US | disclosed |