SCHEMBL7660944

SCHEMBL7660944

COc1cc2ncnc(N3CCN(C(NCc4cccc(Cl)c4)=C(C#N)C#N)CC3)c2cc1OC

nearest known ligand 0.75

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 20/20 0.75
PDGFRA P16234 16/20 0.75
KIT P10721 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7666860 0.91 PDGFRB (0.73) PDGFRBPDGFRAKIT
SCHEMBL7659165 0.87 PDGFRB (0.75) PDGFRBPDGFRAKIT
SCHEMBL7655714 0.87 PDGFRB (0.75) PDGFRBPDGFRAKIT
SCHEMBL7655717 0.87 PDGFRB (0.75) PDGFRBPDGFRAKIT
SCHEMBL7664045 0.86 PDGFRB (0.61) PDGFRBPDGFRAKIT
SCHEMBL7666321 0.86 PDGFRB (0.73) PDGFRBPDGFRAKIT
SCHEMBL7666603 0.86 PDGFRB (0.74) PDGFRBPDGFRAKIT
SCHEMBL6786121 0.85 PDGFRB (1.00) PDGFRBPDGFRAKIT
SCHEMBL7657486 0.84 PDGFRB (0.75) PDGFRBPDGFRAKIT
SCHEMBL7659705 0.83 PDGFRB (0.62) PDGFRBPDGFRAKIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6423716-B1 Nitrogenous heterocyclic compounds KYOWA HAKKO KOGYO CO., LTD. (JP) 2002-07-23 US disclosed
EP-1067123-A1 NITROGENOUS HETEROCYCLIC COMPOUNDS KYOWA HAKKO KOGYO CO., LTD. (JP) 2001-01-10 EP disclosed