Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 13/20 | 0.44 |
| ▸ | CA1 | P00915 | 10/20 | 0.44 |
| ▸ | CA12 | O43570 | 9/20 | 0.44 |
| ▸ | CA9 | Q16790 | 9/20 | 0.44 |
| ▸ | CA7 | P43166 | 6/20 | 0.44 |
| ▸ | CA4 | P22748 | 5/20 | 0.44 |
| ▸ | CA5A | P35218 | 5/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.44 |
| ▸ | CA6 | P23280 | 4/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.44 |
| ▸ | CA3 | P07451 | 2/20 | 0.44 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595311 | 0.93 | PTPN1 (0.39) | PTPN1CA2CA1CA12CA9 | |
| SCHEMBL7592239 | 0.87 | PTPN1 (0.50) | PTPN1CA2CA1CA12CA9 | |
| SCHEMBL7188776 | 0.86 | PTPN1 (0.49) | PTPN1CA2CA1CA12CA9 | |
| SCHEMBL7595806 | 0.83 | PTPN1 (0.39) | PTPN1CA2CA1CA12CA9 | |
| SCHEMBL7594100 | 0.83 | PTPN1 (0.48) | PTPN1 | |
| SCHEMBL7198006 | 0.82 | PTPN1 (0.42) | PTPN1MAPT | |
| SCHEMBL7594291 | 0.81 | PTPN1 (0.34) | PTPN1 | |
| SCHEMBL7594116 | 0.80 | PTPN1 (0.38) | PTPN1CA2CA1CA12CA9 | |
| SCHEMBL7193468 | 0.80 | PTPN1 (0.45) | PTPN1CA2NPC1 | |
| SCHEMBL7181995 | 0.80 | PTPN1 (0.37) | PTPN1CA2CA1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498151-B2 | PROTEIN TYROSINE PHOSPHATASES INHIBITORS, ESPECIALLY AS ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2002-12-24 | — | — | US | claimed |