Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PNP | P00491 | 2/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7105150 | 0.75 | HTT (0.38) | HTTRAB9APNP | |
| SCHEMBL7105302 | 0.70 | HTT (0.40) | HTTRAB9APNP | |
| SCHEMBL7660873 | 0.69 | HTT (0.49) | HTTRAB9APNPPDCD1CD274 | |
| SCHEMBL22973716 | 0.67 | HTT (0.39) | HTTRAB9A | |
| SCHEMBL1420821 | 0.67 | HTT (0.50) | HTTRAB9A | |
| SCHEMBL21278561 | 0.67 | CYP2A6 (0.41) | — | |
| SCHEMBL2728918 | 0.66 | CYP2A6 (0.47) | — | |
| Hydrochloric Acid SCHEMBL6748936 | 0.65 | MAPT (0.40) | — | |
| SCHEMBL22973719 | 0.65 | HTT (0.37) | HTTRAB9A | |
| SCHEMBL7663573 | 0.64 | PNP (0.36) | PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |