Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 8/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.41 |
| ▸ | CDK2 | P24941 | 8/20 | 0.41 |
| ▸ | CTSL | P07711 | 5/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674135 | 0.94 | PDGFRA (0.43) | PDGFRACCNE1CDK2CTSLADORA2A | |
| SCHEMBL7661594 | 0.94 | CDK2 (0.43) | PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7365457 | 0.92 | PDGFRA (0.39) | PDGFRACCNE1CDK2CTSLNR3C1 | |
| SCHEMBL7661658 | 0.92 | PDGFRA (0.38) | PDGFRACCNE1CDK2CTSLADORA2A | |
| SCHEMBL7670257 | 0.92 | PDGFRA (0.38) | PDGFRACCNE1CDK2CTSLNR3C1 | |
| SCHEMBL7356565 | 0.92 | PDGFRA (0.38) | PDGFRACCNE1CDK2CTSLADORA2A | |
| SCHEMBL7670268 | 0.92 | CDK2 (0.38) | PDGFRACCNE1CDK2CTSLADORA2A | |
| SCHEMBL7668529 | 0.92 | PDGFRA (0.38) | PDGFRACCNE1CDK2CTSLADORA2A | |
| SCHEMBL7358385 | 0.92 | CDK2 (0.39) | PDGFRACCNE1CDK2CTSLADORA2A | |
| SCHEMBL7668358 | 0.91 | CCNE1 (0.39) | PDGFRACCNE1CDK2CTSLNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |