Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 4/20 | 0.69 |
| ▸ | TACR2 | P21452 | 19/20 | 0.69 |
| ▸ | TACR3 | P29371 | 4/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL7667751 | 1.00 | TACR2 (0.69) | TACR2TACR1TACR3 | |
| Citric Acid SCHEMBL7666351 | 1.00 | TACR2 (0.69) | TACR2TACR1TACR3 | |
| Citric Acid SCHEMBL7666348 | 1.00 | TACR2 (0.69) | TACR2TACR1TACR3 | |
| Citric Acid SCHEMBL7674178 | 1.00 | TACR2 (0.69) | TACR2TACR1TACR3 | |
| Citric Acid SCHEMBL7668756 | 0.96 | TACR2 (0.64) | TACR2TACR1TACR3 | |
| Citric Acid SCHEMBL7668750 | 0.96 | TACR2 (0.64) | TACR2TACR1TACR3 | |
| Citric Acid SCHEMBL7668754 | 0.96 | TACR2 (0.64) | TACR2TACR1TACR3 | |
| Citric Acid SCHEMBL7676204 | 0.95 | TACR2 (0.66) | TACR2TACR1TACR3 | |
| Citric Acid SCHEMBL7669242 | 0.95 | TACR2 (0.66) | TACR2TACR1TACR3 | |
| Citric Acid SCHEMBL7674140 | 0.95 | TACR2 (0.69) | TACR2TACR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365602-B1 | FOR THERAPY OF DEPRESSION, ANXIETY, ASTHMA, PAIN, INFLAMMATION, URINARY INCONTINENCE AND OTHER DISEASE CONDITIONS | ASTRA ZENECA AB (SE) | 2002-04-02 | — | — | US | disclosed |