Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9763996 | 0.78 | METAP1 (0.37) | METAP1TSHR | |
| SCHEMBL1782548 | 0.78 | METAP1 (0.41) | METAP1TSHRCYP3A4NFKB1NPSR1 | |
| SCHEMBL8751399 | 0.78 | METAP1 (0.37) | METAP1TSHR | |
| SCHEMBL4653098 | 0.76 | TSHR (0.40) | METAP1TSHRFDPS | |
| SCHEMBL4620572 | 0.75 | — | — | |
| SCHEMBL22027595 | 0.73 | TSHR (0.44) | METAP1TSHRCYP3A4NFKB1NPSR1 | |
| SCHEMBL598768 | 0.73 | TSHR (0.44) | METAP1TSHRCYP3A4NFKB1NPSR1 | |
| SCHEMBL1572707 | 0.72 | CHRM1 (0.52) | METAP1TSHRCYP3A4NFKB1NPSR1 | |
| SCHEMBL27283322 | 0.72 | TSHR (0.36) | TSHR | |
| SCHEMBL20489974 | 0.72 | METAP1 (0.41) | METAP1TSHRCYP3A4NFKB1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6348474-B1 | COMPOUNDS AS ANTIDIABETIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-19 | — | — | US | disclosed |
| US-5066696-A | Tertiary-Alkyl-Substituted Melamines | ROHM AND HAAS COMPANY (US) | 1991-11-19 | — | — | US | disclosed |
| EP-0442680-A1 | Polymers stabilized against light and heat degradation | ROHM AND HAAS COMPANY (US) | 1991-08-21 | — | — | EP | disclosed |
| CN-1010019-B | Process for preparing N-formyl phosphonamidothioates | SHELL INT RESEARCH (NL) | 1990-10-17 | — | — | CN | disclosed |
| CN-86106331-A | N-formyl radical sulfo-phosphonic amide ester | — | 1987-06-03 | — | — | CN | disclosed |