Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670614 | 1.00 | ADORA1 (0.47) | ADORA1EGFRMAPK1CYP3A4CYP2C9 | |
| SCHEMBL7670620 | 1.00 | ADORA1 (0.47) | ADORA1EGFRMAPK1CYP3A4CYP2C9 | |
| SCHEMBL6890986 | 0.88 | ADORA1 (0.51) | ADORA1EGFRMAPK1IGF1R | |
| SCHEMBL7660866 | 0.88 | ADORA1 (0.51) | ADORA1EGFRMAPK1IGF1R | |
| SCHEMBL7660851 | 0.88 | ADORA1 (0.51) | ADORA1EGFRMAPK1IGF1R | |
| SCHEMBL7664895 | 0.80 | ADORA1 (0.49) | ADORA1EGFRMAPK1HTTKDM4E | |
| SCHEMBL7661892 | 0.80 | ADORA1 (0.47) | ADORA1EGFRMAPK1CYP3A4CYP2C9 | |
| SCHEMBL7661893 | 0.80 | ADORA1 (0.47) | ADORA1EGFRMAPK1CYP3A4CYP2C9 | |
| SCHEMBL7662071 | 0.80 | ADORA1 (0.52) | ADORA1EGFRMAPK1IGF1R | |
| SCHEMBL7660830 | 0.79 | ADORA1 (0.49) | ADORA1EGFRMAPK1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355640-B1 | TREATMENT OF HYPERTENSION, UROGENITAL DISORDERS AND FORMED BY WITTIG REACTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-12 | — | — | US | disclosed |
| EP-0737193-A1 | PYRAZOLOPYRIDINE ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-16 | — | — | EP | disclosed |
| WO-1995018128-A1 | PYRAZOLOPYRIDINE ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-06 | — | — | WO | disclosed |