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Sugi Predict / Compounds / SCHEMBL7671846

SCHEMBL7671846

SCHEMBL7671846

CCOC(=O)N1c2cc(OC)c(OC)cc2C(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1C

nearest known ligand 0.55

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ CETP P11597 20/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7671838 1.00 CETP (0.55) CETP
SCHEMBL6592123 0.94 CETP (0.51) CETP
SCHEMBL6592128 0.94 CETP (0.51) CETP
SCHEMBL6588585 0.92 CETP (0.64) CETP
SCHEMBL1436313 0.92 CETP (0.60) CETP
SCHEMBL995258 0.92 CETP (0.60) CETP
SCHEMBL6588586 0.92 CETP (0.64) CETP
SCHEMBL6586599 0.92 CETP (0.55) CETP
SCHEMBL6586605 0.92 CETP (0.55) CETP
SCHEMBL6586400 0.91 CETP (0.55) CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6489478-B1 CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INHIBITORS AND THE USE OF SUCH INHIBITORS TO ELEVATE CERTAIN PLASMA LIPID LEVELS, INCLUDING HIGH DENSITY LIPOPROTEIN-CHOLESTEROL AND TO LOWER CERTAIN PFIZER INC. 2002-12-03 — — US disclosed
US-6140343-A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS WHICH ARE USED TO ELEVATE HIGHDENSITY LIPOPROTEIN-CHOLESTEROL AND TO LOWER LOW DENSITY LIPOPROTEIN-CHOLESTEROL AND TRIGLYCERIDES; FOR TREATING ATHEROSCLEROSIS, PERIPHERAL VASCULAR DISEASE, OBESITY PFIZER (US) 2000-10-31 — — US disclosed