Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.41 |
| ▸ | IGF1R | P08069 | 5/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664310 | 0.90 | CDK2 (0.42) | CDK2CCNE1PDGFRAIGF1RCCNE2 | |
| SCHEMBL7666193 | 0.89 | CDK2 (0.41) | CDK2CCNE1PDGFRAIGF1RCCNE2 | |
| SCHEMBL7668416 | 0.87 | CCNE1 (0.41) | CDK2CCNE1PDGFRAIGF1RCCNE2 | |
| SCHEMBL7666197 | 0.87 | CDK2 (0.40) | CDK2CCNE1PDGFRAIGF1RCCNE2 | |
| SCHEMBL7670174 | 0.87 | CDK2 (0.40) | CDK2CCNE1PDGFRAIGF1RCCNE2 | |
| SCHEMBL7666399 | 0.87 | CDK2 (0.40) | CDK2CCNE1PDGFRAIGF1RTRPV1 | |
| SCHEMBL7672349 | 0.84 | SLC29A1 (0.43) | CDK2CCNE1PDGFRAIGF1REGFR | |
| SCHEMBL7668775 | 0.82 | PDGFRA (0.42) | CDK2CCNE1PDGFRACTSLEGFR | |
| SCHEMBL7358385 | 0.82 | CDK2 (0.39) | CDK2CCNE1PDGFRACTSLKDR | |
| SCHEMBL7668634 | 0.76 | CCNE1 (0.54) | CDK2CCNE1PDGFRACCNE2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |