Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 6/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 5/20 | 0.46 |
| ▸ | MMP2 | P08253 | 5/20 | 0.46 |
| ▸ | MMP9 | P14780 | 5/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673871 | 1.00 | KDM4E (0.51) | KDM4EMAPTMAPK1GFEREGFR | |
| SCHEMBL7669658 | 0.88 | MAPK1 (0.49) | KDM4EMAPTMAPK1GFERFLT3 | |
| SCHEMBL6999315 | 0.88 | MAPK1 (0.49) | KDM4EMAPTMAPK1GFERFLT3 | |
| SCHEMBL7000998 | 0.87 | KDM4E (0.46) | KDM4EMAPTMAPK1GFERNPC1 | |
| SCHEMBL7676514 | 0.87 | KDM4E (0.46) | KDM4EMAPTMAPK1GFERNPC1 | |
| SCHEMBL7674637 | 0.81 | MAPT (0.54) | KDM4EMAPTEGFRFLT3MEN1 | |
| SCHEMBL7004430 | 0.81 | MAPT (0.54) | KDM4EMAPTEGFRFLT3MEN1 | |
| SCHEMBL7003372 | 0.77 | MAPK1 (0.54) | KDM4EMAPTMAPK1GFERMEN1 | |
| SCHEMBL7001709 | 0.77 | MAPK1 (0.47) | KDM4EMAPTMAPK1GFERFLT3 | |
| SCHEMBL6994736 | 0.75 | KDM4E (0.61) | KDM4EMAPTMAPK1GFERFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | claimed |